INFLUENCE OF VARIOUS SURGICAL INTERVENTIONS ON VASCULAR WALL APOPTOSIS INDICES IN PATIENTS WITH ATHEROSCLEROSIS OF PERIPHERAL ARTERIES

Objective. Assessment of apoptosis proteins Bcl-2 and Bax indices before after the open vascular reconstructions X-ray endovascular interventions in patients with peripheral atherosclerosis arteries lower extremities. Methods. The study included (n=40) extremities (stage III-IV) disease who underwent surgery - group A, B. Two were analyzed blood serum: initially surgery, on 1<sup>st</sup> day 1 month. reference values studied parameters determined 40 healthy volunteers. Results. Initial protein index 27.1 ng / ml (р<0,001) elevated A reduced 4.4 (p=0.00008) B compared volunteers (16.5 ml, 5.3 respectively). On operative groups there was an increasing tendency for to 35.6 (p<0.001) 25.6 ng/ml By end month, increased 28 3.0 (p=0.039) initial indices; B, only 23.9 increased. Conclusion. Open intervention leads activation pro-apoptotic surgery. In postoperative period reconstruction evaluation potential comparison form reducing by first What this paper adds dynamics changes markers at different periods has been firstly It found that a sufficient proapoptotic potential, i.e. month intervention.